Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

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Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure. / Rubio, Camila Peres; Saril, Ahmet; Kocaturk, Meriç; Tanaka, Ryou; Koch, Jorgen; Ceron, Jose Joaquin; Yilmaz, Zeki.

I: BMC Veterinary Research, Bind 16, Nr. 1, 433, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Rubio, CP, Saril, A, Kocaturk, M, Tanaka, R, Koch, J, Ceron, JJ & Yilmaz, Z 2020, 'Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure', BMC Veterinary Research, bind 16, nr. 1, 433. https://doi.org/10.1186/s12917-020-02650-7

APA

Rubio, C. P., Saril, A., Kocaturk, M., Tanaka, R., Koch, J., Ceron, J. J., & Yilmaz, Z. (2020). Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure. BMC Veterinary Research, 16(1), [433]. https://doi.org/10.1186/s12917-020-02650-7

Vancouver

Rubio CP, Saril A, Kocaturk M, Tanaka R, Koch J, Ceron JJ o.a. Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure. BMC Veterinary Research. 2020;16(1). 433. https://doi.org/10.1186/s12917-020-02650-7

Author

Rubio, Camila Peres ; Saril, Ahmet ; Kocaturk, Meriç ; Tanaka, Ryou ; Koch, Jorgen ; Ceron, Jose Joaquin ; Yilmaz, Zeki. / Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure. I: BMC Veterinary Research. 2020 ; Bind 16, Nr. 1.

Bibtex

@article{ef3b224eb2004628808327211dbd1db9,
title = "Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure",
abstract = "Background: Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results: KC-like was significantly increased in dogs of stage-C (P < 0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01). Conclusion: Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.",
keywords = "Chemokines, Cytokines, Dogs, Heart failure, Inflammation, Oxidative stress",
author = "Rubio, {Camila Peres} and Ahmet Saril and Meri{\c c} Kocaturk and Ryou Tanaka and Jorgen Koch and Ceron, {Jose Joaquin} and Zeki Yilmaz",
year = "2020",
doi = "10.1186/s12917-020-02650-7",
language = "English",
volume = "16",
journal = "B M C Veterinary Research",
issn = "1746-6148",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

AU - Rubio, Camila Peres

AU - Saril, Ahmet

AU - Kocaturk, Meriç

AU - Tanaka, Ryou

AU - Koch, Jorgen

AU - Ceron, Jose Joaquin

AU - Yilmaz, Zeki

PY - 2020

Y1 - 2020

N2 - Background: Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results: KC-like was significantly increased in dogs of stage-C (P < 0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01). Conclusion: Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.

AB - Background: Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results: KC-like was significantly increased in dogs of stage-C (P < 0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01). Conclusion: Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.

KW - Chemokines

KW - Cytokines

KW - Dogs

KW - Heart failure

KW - Inflammation

KW - Oxidative stress

U2 - 10.1186/s12917-020-02650-7

DO - 10.1186/s12917-020-02650-7

M3 - Journal article

C2 - 33167963

AN - SCOPUS:85095703346

VL - 16

JO - B M C Veterinary Research

JF - B M C Veterinary Research

SN - 1746-6148

IS - 1

M1 - 433

ER -

ID: 251586783